New NDM-1 genetically modified gram-negative bacteria superbug threat
An enzyme responsible for a new class of super bacteria with a genetically modified defense - NDM-1 - which makes the bacteria carrying it immune to most or all known anti-biotics has infection experts alarmed. The multi-drug resistance facilitated by the gene New Delhi metallo-beta-lactamase or NDM-1 can easily jump from one strain of bacteria to another, possibly creating a pandemic of resistant infections.
The bacteria with the modified genetics have been found world-wide.
So far all the bugs which have this extra-chromosomal DNA are gram-negative, which are a more complex bacteria with a double cell wall. Today, most pharmaceutical companies are not making drugs to combat these types of bacteria because the gram-negative, double-cell walled bugs are more difficult to combat and kill. For gram-negative bacteria, the pipeline of new and developing antibiotics and drugs is essentially dry.
QuorumEx's first product, Topic-QX has been shown to be highly effective in the disruption of gram-negative bacterial quorum sensing.
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