Halos indicating QS disruption from plant compounds
Posted Wed, 2010/04/07 - 8:53pm
- Tags:
- illustration,
- halo,
- control,
- Chromobacterium violaceum,
- biomonitor,
- bacteria,
- antiquorum sensing,
- anti-qs,
- quorum sensing disruption,
- QS disruption,
- petri dish,
- testplate
Comments
Explanation of graphic
Another view of a biomonitor strain of bacteria, Chromobacterium violaceum, which excretes a pigment when a quorum has been sensed. The top discs are plant extracts and compounds surrounded with gradient "halos" which demonstrate an anti-quorum sensing effect.
The bottom 3 discs are (from left-right) an anti-bacterial agent (gentamicin), control, and a standard anti-qs compound. The gentamicin anti-bacterial shows a complete loss of quorum sensing around the disc, as the brute-force technique of destroying and killing all the bacteria results in the loss of QS, and thus pigment generation.
The top row of plant-based anti-qs compounds with a gradient "halo" around them, demonstrate that the quorum sensing ability of the bacteria has been eliminated, yet the bacteria still remain alive and well, thus not forcing the evolutionary hand. We believe this is a novel, new approach to dealing with the pathogenisis of other bacteria by turning their quorum sensing ability off, as opposed to outright destroying them.